In Greek mythology, Antíphatês (in Latin) or Antiphátês (Ἀντιφάτης in Ancient Greek) is the name of five characters.
- Antíphatês, King of the Laestrygones, a mythological tribe of gigantic cannibals. He was married and had a daughter. When he was visited by a scouting party sent by Odysseus, he ate one of the men on the spot and raised a hue-and-cry to ensure most of the rest of Odysseus' company would be hunted down.
- Antíphatês, a Trojan warrior, slain by Leonteus.
- Antíphatês, son of Melampus and Iphianeira, the daughter of Megapenthes. He married Zeuxippe, the daughter of Hippocoon. Their children were Oecles and Amphalces. 
- Antíphatês, one of Greek warriors who hid in the Trojan horse.
- Antíphatês, son of Sarpedon. Who accompanied Aeneas to Italy where he was killed by Turnus.