In Greek mythology, Hippothoe is the name of five distinct characters. The name means "Imperious mare".
- Hippothoe was a daughter of Mestor, son of Perseus, and of Lysidice, daughter of Pelops. Poseidon abducted Hippothoe from her family and took her to the Ekhidnades islands. Upon her he sired Taphius who later founded the city of Taphos.
- Hippothoe was one of the Nereids.
- Hippothoe was a daughter of Pelias. Her mother was either Anaxibia, daughter of Bias, or Phylomache, one of the Niobids
- Hippothoe an amazon. She fought with Penthesilea at Troy and was killed by Achilles 
- Hippothoe, one of the Danaids, daughter of Danaus. She married Obrimus, son of Aegyptus.